DNA Replication and Repair Laboratory

The De Biasio Lab uses Cryo-EM to study DNA Replication and Repair Complexes

Selected Publications

Structural dynamics of DNA unwinding by a replicative helicase

Year: 2025 DOI:10.1038/s41586-025-08766-w

Authors: Taha Shahid, Ammar U. Danazumi, Muhammad Tehseen, Lubna Alhudhali, Alice R. Clark, Christos G. Savva, Samir M. Hamdan and Alfredo De Biasio

Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing

Year: 2022 DOI:https://doi.org/10.1038/s41467-022-35475-z

Authors: Kerry Blair, Muhammad Tehseen, Vlad-Stefan Raducanu, Taha Shahid, Claudia Lancey, Fahad Rashid, Ramon Crehuet, Samir M. Hamdan & Alfredo De Biasio

Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA

Year: 2022 DOI:https://doi.org/10.1038/s41467-021-26251-6

Authors: Claudia Lancey, Muhammad Tehseen, Souvika Bakshi, Matthew Percival, Masateru Takahashi, Mohamed A. Sobhy, Vlad S. Raducanu, Kerry Blair, Frederick W. Muskett, Timothy J. Ragan, Ramon Crehuet, Samir M. Hamdan & Alfredo De Biasio

Our work Visualised in Context within a Movie

Our work in the Protein Data Bank (PDB)

The 3D molecular models from our group

Explore our structures in the PDB

Our work in the News

Read about our research in KAUST discovery

Our research in the news