Publications

Structural dynamics of DNA unwinding by a replicative helicase

Year: 2025 DOI:10.1038/s41586-025-08766-w

Authors: Taha Shahid, Ammar U. Danazumi, Muhammad Tehseen, Lubna Alhudhali, Alice R. Clark, Christos G. Savva, Samir M. Hamdan and Alfredo De Biasio

Structure of Aquifex aeolicus lumazine synthase by cryo-electron microscopy to 1.42 Å resolution

Year: 2024 ISSN:2052-2525 DOI:10.1107/S2052252524005530

Authors: Christos G. Savva, Mohamed A. Sobhy, Alfredo De Biasio and Samir M. Hamdan

Severe Combined Immunodeficiency from a Homozygous DNA Ligase 1 Mutant with Reduced Catalytic Activity but Increased Ligation Fidelity

Year: 2024 DOI:10.1007/s10875-024-01754-1

Authors: Huda Alajlan, Vlad-Stefan Raducanu, Yossef Lopez de los Santos, Muhammad Tehseen, Hibah Alruwaili, Amer Al-Mazrou, Reem Mohammad, Monther Al-Alwan, Alfredo De Biasio, Jasmeen S. Merzaban, Hamoud Al-Mousa, Samir M. Hamdan, Anas M. Alazami.

Single-molecule characterization of SV40 replisome and novel factors: human FPC and Mcm10

Year: 2024 DOI:10.1093/nar/gkae565

Authors: Yujin Ouyang, Amani Al-Amodi, Muhammed Tehseen, Lubna Alhudhali, Afnan Shirbini, Masateru Takahashi, Vlad-Stefan Raducanu, Gang Yi, Ammar Usman Danazumi, Alfredo De Biasio, Samir M Hamdan

Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing

Year: 2022 DOI:https://doi.org/10.1038/s41467-022-35475-z

Authors: Kerry Blair, Muhammad Tehseen, Vlad-Stefan Raducanu, Taha Shahid, Claudia Lancey, Fahad Rashid, Ramon Crehuet, Samir M. Hamdan & Alfredo De Biasio

Implementing Fluorescence Enhancement, Quenching, and FRET for Investigating Flap Endonuclease 1 Enzymatic Reaction at the Single-Molecule Level

Year: 2021 DOI:https://doi.org/10.1016/j.csbj.2021.07.029

Authors: Mohamed A Sobhy , Muhammad Tehseen, Masateru Takahashi, Amer Bralić, Alfredo De Biasio, Samir M Hamdan

Functional hierarchy of PCNA-interacting motifs in DNA processing enzymes

Year: 2023 DOI:https://doi.org/10.1002/bies.202300020

Authors: Samir M Hamdan, Alfredo De Biasio

Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics

Year: 2022 DOI:https://doi.org/10.1038/s41467-022-34751-2

Authors: Vlad-Stefan Raducanu, Muhammad Tehseen, Amani Al-Amodi, Luay I. Joudeh, Alfredo De Biasio & Samir M. Hamdan

Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA

Year: 2022 DOI:https://doi.org/10.1038/s41467-021-26251-6

Authors: Claudia Lancey, Muhammad Tehseen, Souvika Bakshi, Matthew Percival, Masateru Takahashi, Mohamed A. Sobhy, Vlad S. Raducanu, Kerry Blair, Frederick W. Muskett, Timothy J. Ragan, Ramon Crehuet, Samir M. Hamdan & Alfredo De Biasio

Structure of the processive human Pol δ holoenzyme

Year: 2020 DOI:10.1038/s41467-020-14898-6

Authors: Claudia Lancey, Muhammad Tehseen, Vlad-Stefan Raducanu, Fahad Rashid, Nekane Merino, Timothy J. Ragan, Christos G. Savva, Manal S. Zaher, Afnan Shirbini, Francisco J. Blanco, Samir M. Hamdan & Alfredo De Biasio